Professor Sherman Klump is getting married. And the Klump family could not be more delighted. His fiancee Denise is thrilled to become a Klump, and with her appetite she’ll fit right in; Mama thinks it’s fabulous; Papa’s less grouchy; Granny’s relieved that Sherman, at long last, will soon be enjoying the pleasures of intimate relations; Ernie’s belligerence has been momentarily simmered, and Ernie Jr. simply can’t wait to feast at the wedding. But Buddy Love... well, Buddy is another matter.

Lovable Sherman thought he had seen the last of his alter-ego, but Buddy Love is back and trying to make it on his own. Having done his best to keep Buddy buried in his subconscious, the portly and painfully-shy professor is horrified to find him resurfacing in untimely outbursts, and threatening his marriage plans to colleague Denise Gaines (Janet Jackson). Utilizing Denise’s cutting-edge DNA research, Sherman decides to rid himself of his monstrous nemesis –and his disruptive outbursts–once and for all by extracting Buddy’s DNA from his system.

But Buddy Love will not go quietly. He bursts full-bodied into Sherman’s world and lays claim to the professor’s astounding invention — a revolutionary youth serum. The serum can turn back time temporarily, shave decades off one’s appearance and restore vitality, making it a hugely lucrative property that everyone’s clamoring for. Desperate to keep it from Buddy, Sherman hides the serum in the Klump family home, thinking it will be safe. (But even Cletus "Papa" Klump finds the serum irresistible, momentarily revisiting the glory — and libidinal wonder of his youth).

Buddy, of course, isn’t to be deterred. His instincts lead him to the Klump home, where Denise’s bachelorette party is in full swing. Creeping around the house, he is confronted by a lascivious Granny Klump, who believes Buddy to be the man of her erotic dreams. Horrified by the septuagenarian siren’s advances, Buddy quickly manages to locate the "youth juice" and steals away. And so begins a race against time as Sherman battles to reclaim his formula, restore order to his family, and marry the woman he loves... before all hell breaks loose.

Universal Pictures and Imagine Entertainment present Nutty Professor II: The Klumps, an explosive comedy starring Eddie Murphy (Dr. Dolittle) and Janet Jackson (Poetic Justice), who are joined by Larry Miller and John Ales from the first The Nutty Professor. Produced by Brian Grazer (Liar Liar, Bowfinger), the film is directed by Peter Segal (Tommy Boy) from a screenplay by Barry W. Blaustein & David Sheffield and Paul Weitz & Chris Weitz (American Pie). Jerry Lewis, Eddie Murphy, Karen Kehela, Tom Shadyac and James D. Brubaker serve as executive producers with James Whitaker and Michael Ewing serving as co-producers.

Academy Award®-winner Dean Semler returns as cinematographer with William Elliott returning as production designer, William Kerr returning as editor with special make-up effects wizard and five-time Academy Award®-winner Rick Baker and visual effects supervisor Jon Farhat also returning. They are joined by costume designer Sharen Davis (Dr. Dolittle) and composer David Newman (The Flintstones in Viva Rock Vegas).